Immunogen
The antiserum was produced against synthesized peptide derived from human RPL22. AA range:51-100
Specificity
Ribosomal Protein L22 Polyclonal Antibody detects endogenous levels of Ribosomal Protein L22 protein.
Formulation
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Dilution rate
IHC: 1/100 - 1/300. ELISA: 1/10000.. IF 1:50-200
Purification process (Immunogen)
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Background
Ribosomes, the organelles that catalyze protein synthesis, consist of a small 40S subunit and a large 60S subunit. Together these subunits are composed of 4 RNA species and approximately 80 structurally distinct proteins. This gene encodes a cytoplasmic ribosomal protein that is a component of the 60S subunit. The protein belongs to the L22E family of ribosomal proteins. Its initiating methionine residue is post-translationally removed. The protein can bind specifically to Epstein-Barr virus-encoded RNAs (EBERs) 1 and 2. The mouse protein has been shown to be capable of binding to heparin. Transcript variants utilizing alternative polyA signals exist. As is typical for genes encoding ribosomal proteins, there are multiple processed pseudogenes of this gene dispersed through the genome. It was previously thought that this gene mapped to 3q26 and that it was fused to the acute myeloid leukemia 1 (AML1
Function
miscellaneous:Binds to Epstein-Barr virus small RNAs and to heparin.,similarity:Belongs to the ribosomal protein L22e family.,
Protein name
60S ribosomal protein L22
Abbreviation
Ribosomal Protein L22
Other name
RPL22; 60S ribosomal protein L22; EBER-associated protein; EAP; Epstein-Barr virus small RNA-associated protein; Heparin-binding protein HBp15
Fields
>>Ribosome;>>Coronavirus disease - COVID-19
Human protein sequence Database
P35268
Mouse protein sequence database
P67984
Rat protein sequence database
P47198
Cellular localization
nucleus,cytoplasm,cytosol,ribosome,focal adhesion,cytosolic large ribosomal subunit,intracellular ribonucleoprotein complex,extracellular matrix,extracellular exosome,
Tissue expression
Brain,Cervix,Cervix carcinoma,Eye,Placenta,Submandibular gland,
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