Molecular weight (DA)
107kD
Immunogen
The antiserum was produced against synthesized peptide derived from human RIN3. AA range:391-440
Specificity
RIN3 Polyclonal Antibody detects endogenous levels of RIN3 protein.
Formulation
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Dilution rate
WB 1:500-2000;IHC-p 1:50-300; ELISA 2000-20000
Purification process (Immunogen)
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Background
Summary: This protein encoded by this gene is a member of the RIN family of Ras interaction-interference proteins, which are binding partners to the RAB5 small GTPases. The protein functions as a guanine nucleotide exchange for RAB5B and RAB31. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Feb 2016],
Function
caution:The region from Asp-168 to Pro-327 is deduced from the genomic sequence by similarity to the mouse sequence.,function:Potential Ras effector protein. May function as a guanine nucleotide exchange (GEF), by exchanging bound GDP for free GTP.,similarity:Belongs to the RIN (Ras interaction/interference) family.,similarity:Contains 1 Ras-associating domain.,similarity:Contains 1 SH2 domain.,similarity:Contains 1 VPS9 domain.,subcellular location:Activation of tyrosine phosphorylation signaling induces translocation to cytoplasmic vesicles.,subunit:Interacts with RAB5B and BIN1.,tissue specificity:Widely expressed.,
Protein name
Ras and Rab interactor 3
Other name
RIN3; Ras and Rab interactor 3; Ras interaction/interference protein 3
Human protein sequence Database
Q8TB24
Mouse protein sequence database
P59729
Rat protein sequence database
Cellular localization
Cytoplasm . Cytoplasmic vesicle . Early endosome . Activation of tyrosine phosphorylation signaling induces translocation to cytoplasmic vesicles. .
Tissue expression
Widely expressed.
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