Molecular weight (DA)
50kD
Immunogen
The antiserum was produced against synthesized peptide derived from human SEPT14. AA range:341-390
Specificity
Septin 14 Polyclonal Antibody detects endogenous levels of Septin 14 protein.
Formulation
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Dilution rate
WB 1:500-2000;IHC-p 1:50-300
Purification process (Immunogen)
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Background
SEPT14 is a member of the highly conserved septin family of GTP-binding cytoskeletal proteins implicated in membrane transport, apoptosis, cell polarity, cell cycle regulation, cytokinesis, and other cellular functions (Peterson et al., 2007 [PubMed 17922164]).[supplied by OMIM, Jul 2008],
Function
function:Involved in cytokinesis .,similarity:Belongs to the septin family.,
Other name
SEPT14; Septin-14
Human protein sequence Database
Q6ZU15
Mouse protein sequence database
Q9DA97
Rat protein sequence database
Cellular localization
Cytoplasm . Cytoplasm, cytoskeleton . Cell projection, axon . Cell projection, dendrite . Perikaryon . Cytoplasm, perinuclear region . Cytoplasmic vesicle, secretory vesicle, acrosome . Colocalizes with actin stress fibers (PubMed:17922164). Expressed in the perinuclear rim and manchette structure in early elongating spermatids during spermiogenesis (By similarity). .
Tissue expression
Testis-specific (at protein level).
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