Immunogen
The antiserum was produced against synthesized peptide derived from human TRIM16. AA range:31-80
Specificity
TRIM16 Polyclonal Antibody detects endogenous levels of TRIM16 protein.
Formulation
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Dilution rate
IHC: 1/100 - 1/300. ELISA: 1/10000.. IF 1:50-200
Purification process (Immunogen)
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Background
This gene was identified as an estrogen and anti-estrogen regulated gene in epithelial cells stably expressing estrogen receptor. The protein encoded by this gene contains two B box domains and a coiled-coiled region that are characteristic of the B box zinc finger protein family. The proteins of this family have been reported to be involved in a variety of biological processes including cell growth, differentiation and pathogenesis. Expression of this gene was detected in most tissues. Its function, however, has not yet been determined. [provided by RefSeq, Jul 2008],
Function
function:May play a role in the regulation of keratinocyte differentiation.,similarity:Belongs to the TRIM/RBCC family.,similarity:Contains 1 B30.2/SPRY domain.,similarity:Contains 2 B box-type zinc fingers.,tissue specificity:Highest levels found in testis, ovary, small intestine, colon, placenta, heart, skeletal muscle and mammary gland. More highly expressed in the fetus than in the corresponding adult tissues. Expressed in basal keratinocytes.,
Protein name
Tripartite motif-containing protein 16
Other name
TRIM16; EBBP; Tripartite motif-containing protein 16; Estrogen-responsive B box protein
Human protein sequence Database
O95361
Mouse protein sequence database
Q99PP9
Rat protein sequence database
Cellular localization
Cytoplasm .
Tissue expression
Highest levels found in testis, ovary, small intestine, colon, placenta, heart, skeletal muscle and mammary gland. More highly expressed in the fetus than in the corresponding adult tissues. Expressed in basal keratinocytes.
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