Molecular weight (DA)
13kD
Immunogen
The antiserum was produced against synthesized peptide derived from the C-terminal region of human TFPI2. AA range:186-235
Specificity
TFPI-2 Polyclonal Antibody detects endogenous levels of TFPI-2 protein.
Formulation
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Dilution rate
Western Blot: 1/500 - 1/2000. ELISA: 1/20000. Not yet tested in other applications.
Purification process (Immunogen)
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Background
This gene encodes a member of the Kunitz-type serine proteinase inhibitor family. The protein can inhibit a variety of serine proteases including factor VIIa/tissue factor, factor Xa, plasmin, trypsin, chymotryspin and plasma kallikrein. This gene has been identified as a tumor suppressor gene in several types of cancer. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Aug 2012],
Function
domain:This inhibitor contains three inhibitory domains.,function:May play a role in the regulation of plasmin-mediated matrix remodeling. Inhibits trypsin, plasmin, factor VIIa/tissue factor and weakly factor Xa. Has no effect on thrombin.,similarity:Contains 2 BPTI/Kunitz inhibitor domains.,similarity:Contains 3 BPTI/Kunitz inhibitor domains.,tissue specificity:Umbilical vein endothelial cells, liver, placenta, heart, pancreas, and maternal serum at advanced pregnancy.,
Protein name
Tissue factor pathway inhibitor 2
Other name
TFPI2; Tissue factor pathway inhibitor 2; TFPI-2; Placental protein 5; PP5
Human protein sequence Database
P48307
Mouse protein sequence database
O35536
Rat protein sequence database
Cellular localization
Secreted.
Tissue expression
Umbilical vein endothelial cells, liver, placenta, heart, pancreas, and maternal serum at advanced pregnancy.
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