Molecular weight (DA)
65kD
Immunogen
Synthesized peptide derived from MIA2 at AA range: 361-410
Specificity
MIA2 Polyclonal Antibody detects endogenous levels of MIA2
Formulation
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Dilution rate
WB 1:500-2000;IHC-p 1:50-300
Purification process (Immunogen)
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Background
This gene encodes s receptor in the endoplasmic reticulum, which plays a role in the export of large pre-chylomicrons and pre-very low density lipoproteins (pre-VLDLs). Three major classes of transcripts are generated from this gene- melanoma inhibitory activity 2-specific transcripts, cTAGE family member 5-specific transcripts and transcripts that include exons from both these transcript species (TANGO1-like or TALI). Additionally, alternative splicing in these transcripts results in multiple transcript variants encoding multiple isoforms. [provided by RefSeq, Sep 2016],
Function
disease:Autoantigen found several cancer types, including benign meningioma and cutaneous T-cell lymphoma (CTCL). Isoform 5A and isoform 5B are recognized by patients' sera with tumor specimen of various origins.,disease:Tumor-associated antigen found in several cutaneous T-cell lymphoma (CTCL). Also found in colorectal and breast carcinomas, head and neck squamous cell carcinomas and melanoma.,function:Tumor-associated antigen.,sequence caution:Translation N-terminally extended.,similarity:Belongs to the cTAGE family.,tissue specificity:At the protein level, isoform 5A is expressed only in testis. Other isoforms are expressed in several other normal tissues, including brain, muscle and cranial skin. Isoform 5A (at the protein level) and isoform 5B are expressed in cutaneous T-cell lymphoma (CTCL) cell lines, colorectal carcinomas, breast carcinomas and melanoma. Isoform 5B, but not isof
Other name
Melanoma inhibitory activity protein 2
Human protein sequence Database
Q96PC5
Mouse protein sequence database
Q91ZV0
Rat protein sequence database
Cellular localization
Endoplasmic reticulum membrane ; Single-pass membrane protein . Localizes to endoplasmic reticulum exit sites (ERES), also known as transitional endoplasmic reticulum (tER). .
Tissue expression
Highly expressed in liver and weakly in testis. Expression was higher in patients with severe fibrosis or inflammation and chronic hepatitis (PubMed:12586826). Isoform 1 is specifically expressed in lung, testis, small intestine, colon, pancreas, kidney, liver and prostate (PubMed:27138255). Isoform 8 is expressed only in testis (at the protein level). Isoform 8 (at protein level) and isoform 9 are expressed in cutaneous T-cell lymphoma (CTCL) cell lines, colorectal carcinomas, breast carcinomas and melanoma. Isoform 9, but not isoform 5A, is expressed in head and neck squamous cell carcinoma (PubMed:12839582).
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