Molecular weight (DA)
78 260kD
Immunogen
Synthesized peptide derived from human NOTCH3 (Cleaved-Asp1628)
Specificity
This antibody detects endogenous levels of Human,Mouse,Rat NOTCH3 (Cleaved-Asp1628, protein was cleaved amino acid sequence between 1628-1629 )
Source
Polyclonal, Rabbit,IgG
Formulation
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Dilution rate
WB 1:1000-2000 ELISA 1:5000-20000
Purification process (Immunogen)
The antibody was affinity-purified from rabbit serum by affinity-chromatography using specific immunogen.
Protein name
NOTCH3 (Cleaved-Asp1628)
Other name
Neurogenic locus notch homolog protein 3 (Notch 3) [Cleaved into: Notch 3 extracellular truncation; Notch 3 intracellular domain]
Fields
>>Endocrine resistance;>>Notch signaling pathway;>>Apelin signaling pathway;>>Th1 and Th2 cell differentiation;>>Thyroid hormone signaling pathway;>>Human papillomavirus infection;>>Pathways in cancer;>>MicroRNAs in cancer;>>Breast cancer
Human protein sequence Database
Q9UM47
Mouse protein sequence database
Q61982
Rat protein sequence database
Q9R172
Cellular localization
Cell membrane ; Single-pass type I membrane protein.; [Notch 3 intracellular domain]: Nucleus. Following proteolytical processing NICD is translocated to the nucleus.
Tissue expression
Ubiquitously expressed in fetal and adult tissues.
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