Molecular weight (DA)
37kD
Immunogen
Purified recombinant human Calumenin protein fragments expressed in E.coli.
Specificity
This antibody detects endogenous levels of Calumenin and does not cross-react with related proteins.
Formulation
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Purification process (Immunogen)
The antibody was affinity-purified from mouse ascites by affinity-chromatography using epitope-specific immunogen.
Background
calumenin(CALU) Homo sapiens The product of this gene is a calcium-binding protein localized in the endoplasmic reticulum (ER) and it is involved in such ER functions as protein folding and sorting. This protein belongs to a family of multiple EF-hand proteins (CERC) that include reticulocalbin, ERC-55, and Cab45 and the product of this gene. Alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq, Oct 2008],
Function
function:Involved in regulation of vitamin K-dependent carboxylation of multiple amino-terminal glutamate residues. Seems to inhibit gamma-carboxylase GGCX. Binds 7 calcium ions with a low affinity.,similarity:Belongs to the CREC family.,similarity:Contains 6 EF-hand domains.,subcellular location:Identified by mass spectrometry in melanosome fractions from stage I to stage IV.,subunit:Interacts with GGCX.,tissue specificity:Ubiquitously expressed. Expressed at high levels in heart, placenta and skeletal muscle, at lower levels in lung, kidney and pancreas and at very low levels in brain and liver.,
Other name
CALU;CALU_HUMAN;Calumenin 1;Calumenin 2;Calumenin;Crocalbin;crocalbin-like protein; FLJ90608;IEF SSP 9302;multiple EF-hand protein;OTTHUMP00000212712;OTTHUMP00000212713; OTTHUMP00000212714;OTTHUMP00000212715.
Human protein sequence Database
O43852
Mouse protein sequence database
O35887
Rat protein sequence database
Cellular localization
Endoplasmic reticulum membrane . Golgi apparatus . Secreted . Melanosome . Sarcoplasmic reticulum lumen . Identified by mass spectrometry in melanosome fractions from stage I to stage IV. .
Tissue expression
Ubiquitously expressed. Expressed at high levels in heart, placenta and skeletal muscle, at lower levels in lung, kidney and pancreas and at very low levels in brain and liver.
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