Molecular weight (DA)
24kD
Immunogen
Purified recombinant human RAB4A protein fragments expressed in E.coli.
Specificity
This antibody detects endogenous levels of RAB4A and does not cross-react with related proteins.
Formulation
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Purification process (Immunogen)
The antibody was affinity-purified from mouse ascites by affinity-chromatography using epitope-specific immunogen.
Background
This gene is a member of the largest group in the Ras superfamily of small GTPases, which regulate membrane trafficking. The encoded protein is associated with early endosomes and is involved in their sorting and recycling. The protein also plays a role in regulating the recycling of receptors from endosomes to the plasma membrane. Alternatively spliced transcript variants have been observed for this gene. [provided by RefSeq, Dec 2012],
Function
function:Protein transport. Probably involved in vesicular traffic.,PTM:Phosphorylated by CDC2 kinase during mitosis.,similarity:Belongs to the small GTPase superfamily. Rab family.,subcellular location:Generally associated with membranes. Cytoplasmic when phosphorylated by CDC2.,subunit:Interacts with RAB11FIP1, RABEP1, ZFYVE20 and RUFY1. Interacts with SGSM1, SGSM2 and SGSM3.,
Other name
HRES 1 / RAB4;Oncogene RAB4;OTTHUMP00000042824;Rab 4;RAB 4A;RAB4 member RAS oncogene family;RAB4A;RAB4A member RAS oncogene family;RAB4A_HUMAN;Ras related protein Rab 4A;Ras related protein Rab4A;Ras-related protein Rab-4A.
Human protein sequence Database
P20338
Mouse protein sequence database
P56371
Rat protein sequence database
Cellular localization
Membrane; Peripheral membrane protein . Cytoplasm . Early endosome membrane ; Peripheral membrane protein . Recycling endosome membrane ; Peripheral membrane protein . Generally associated with membranes. Cytoplasmic when phosphorylated by CDK1. .
Tissue expression
Brain,Caudate nucleus,Cervix carcinoma,Human small intestine,Skin,U
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