Molecular weight (DA)
15-20kD
Immunogen
Recombinant protein of human 4E-BP2.
Specificity
Transfected Only.
Formulation
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Dilution rate
wb dilution 1:1000
Purification process (Immunogen)
The antibody was affinity-purified from mouse ascites by affinity-chromatography using epitope-specific immunogen.
Background
eukaryotic translation initiation factor 4E binding protein 2(EIF4EBP2) Homo sapiens This gene encodes a member of the eukaryotic translation initiation factor 4E binding protein family. The gene products of this family bind eIF4E and inhibit translation initiation. However, insulin and other growth factors can release this inhibition via a phosphorylation-dependent disruption of their binding to eIF4E. Regulation of protein production through these gene products have been implicated in cell proliferation, cell differentiation and viral infection. [provided by RefSeq, Oct 2008],
Function
function:Regulates eIF4E activity by preventing its assembly into the eIF4F complex. Mediates the regulation of protein translation by hormones, growth factors and other stimuli that signal through the MAP kinase pathway.,PTM:Phosphorylated on serine and threonine residues in response to insulin, EGF and PDGF.,similarity:Belongs to the eIF4E-binding protein family.,subunit:Nonphosphorylated EIF4EBP2 interacts with EIF4E.,
Other name
4E-BP2 ; 4EBP2 ; 4EBP2_HUMAN ; eIF4E binding protein 2 ; eIF4E-binding protein 2 ; Eif4ebp2 ; Eukaryotic translation initiation factor 4E binding protein 1 ; Eukaryotic translation initiation factor 4E-binding protein 2 ; PHASII ; phosphorylated, heat and acid stable regulated by insulin protein II.
Fields
>>Longevity regulating pathway - multiple species
Human protein sequence Database
Q13542
Mouse protein sequence database
P70445
Rat protein sequence database
Cellular localization
intracellular,cytoplasm,
Tissue expression
Lung,Placenta,Uterus,
Contract Us
Follow Us
Location： 
Specification
成功添加到购物车