Molecular weight (DA)
71kD
Immunogen
Synthesized peptide derived from human protein . at AA range: 340-420
Specificity
FOXN1 Polyclonal Antibody detects endogenous levels of protein.
Formulation
Liquid in PBS containing 50% glycerol, and 0.02% sodium azide.
Dilution rate
WB 1:500-2000 ELISA 1:5000-20000
Purification process (Immunogen)
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Background
Mutations in the winged-helix transcription factor gene at the nude locus in mice and rats produce the pleiotropic phenotype of hairlessness and athymia, resulting in a severely compromised immune system. This gene is orthologous to the mouse and rat genes and encodes a similar DNA-binding transcription factor that is thought to regulate keratin gene expression. A mutation in this gene has been correlated with T-cell immunodeficiency, the skin disorder congenital alopecia, and nail dystrophy. Alternative splicing in the 5' UTR of this gene has been observed. [provided by RefSeq, Jul 2008],
Function
disease:Defects in FOXN1 are the cause of T-cell immunodeficiency congenital alopecia and nail dystrophy [MIM:601705].,function:Transcriptional regulator involved in development.,online information:FOXN1 mutation db,similarity:Contains 1 fork-head DNA-binding domain.,tissue specificity:Expressed in thymus.,
Protein name
Forkhead box protein N1 (Winged-helix transcription factor nude)
Human protein sequence Database
O15353
Mouse protein sequence database
Q61575
Rat protein sequence database
Cellular localization
Nucleus.
Tissue expression
Expressed in thymus.
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