Molecular weight (DA)
31kD
Immunogen
Synthesized peptide derived from human protein . at AA range: 210-290
Specificity
ZMAT3 Polyclonal Antibody detects endogenous levels of protein.
Formulation
Liquid in PBS containing 50% glycerol, and 0.02% sodium azide.
Dilution rate
WB 1:500-2000 ELISA 1:5000-20000
Purification process (Immunogen)
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Background
This gene encodes a protein containing three zinc finger domains and a nuclear localization signal. The mRNA and the protein of this gene are upregulated by wildtype p53 and overexpression of this gene inhibits tumor cell growth, suggesting that this gene may have a role in the p53-dependent growth regulatory pathway. Alternative splicing of this gene results in two transcript variants encoding two isoforms differing in only one amino acid. [provided by RefSeq, Jul 2008],
Function
function:Acts as a bona fide target gene of p53. May play a role in the p53-dependent growth regulatory pathway. May contribute to p53-mediated apoptosis by regulation of p53 expression and translocation to the nucleus and nucleolus.,induction:By DNA damage in a p53-dependent manner. Up-regulated following ionizing radiation in primary squamous cell carcinoma of the lung and in various colon cancer cell lines.,similarity:Contains 3 matrin-type zinc fingers.,subunit:Interacts with dsRNA.,tissue specificity:Highly expressed in adult brain, and moderately in adult kidney and testis. Not detected in fetal brain, heart, pancreas, adrenal gland, liver or small intestine.,
Gene Name
ZMAT3 PAG608 WIG1
Protein name
Zinc finger matrin-type protein 3 (Zinc finger protein WIG-1) (p53-activated gene 608 protein)
Fields
>>p53 signaling pathway
Human protein sequence Database
Q9HA38
Mouse protein sequence database
O54836
Rat protein sequence database
O08781
Cellular localization
Nucleus . Nucleus, nucleolus .
Tissue expression
Highly expressed in adult brain, and moderately in adult kidney and testis. Not detected in fetal brain, heart, pancreas, adrenal gland, liver or small intestine.
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