Molecular weight (DA)
127kD
Immunogen
Synthesized peptide derived from human protein . at AA range: 740-820
Specificity
BMP2K Polyclonal Antibody detects endogenous levels of protein.
Formulation
Liquid in PBS containing 50% glycerol, and 0.02% sodium azide.
Dilution rate
WB 1:500-2000 ELISA 1:5000-20000
Purification process (Immunogen)
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Background
This gene is the human homolog of mouse BMP-2-inducible kinase. Bone morphogenic proteins (BMPs) play a key role in skeletal development and patterning. Expression of the mouse gene is increased during BMP-2 induced differentiation and the gene product is a putative serine/threonine protein kinase containing a nuclear localization signal. Therefore, the protein encoded by this human homolog is thought to be a protein kinase with a putative regulatory role in attenuating the program of osteoblast differentiation. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008],
Function
catalytic activity:ATP + a protein = ADP + a phosphoprotein.,function:May be involved in osteoblast differentiation.,PTM:Autophosphorylated.,similarity:Belongs to the protein kinase superfamily. Ser/Thr protein kinase family.,similarity:Contains 1 protein kinase domain.,
Gene Name
BMP2K BIKE HRIHFB2017
Protein name
BMP-2-inducible protein kinase (BIKe) (EC 2.7.11.1)
Fields
>>Transcriptional misregulation in cancer
Human protein sequence Database
Q9NSY1
Mouse protein sequence database
Q91Z96
Rat protein sequence database
Cellular localization
Nucleus .
Tissue expression
Brain,Epithelium,Ovary,Synovial membrane tissue,Testis,Thyroid,
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