Molecular weight (DA)
298kD
Immunogen
Synthesized peptide derived from human protein . at AA range: 1060-1140
Specificity
MLL4 Polyclonal Antibody detects endogenous levels of protein.
Formulation
Liquid in PBS containing 50% glycerol, and 0.02% sodium azide.
Dilution rate
IHC-p 1:50-300. IF 1:50-200
Purification process (Immunogen)
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Background
This gene encodes a protein which contains multiple domains including a CXXC zinc finger, three PHD zinc fingers, two FY-rich domains, and a SET (suppressor of variegation, enhancer of zeste, and trithorax) domain. The SET domain is a conserved C-terminal domain that characterizes proteins of the MLL (mixed-lineage leukemia) family. This gene is ubiquitously expressed in adult tissues. It is also amplified in solid tumor cell lines, and may be involved in human cancer. Two alternatively spliced transcript variants encoding distinct isoforms have been reported for this gene, however, the full length nature of the shorter transcript is not known. [provided by RefSeq, Jul 2008],
Function
catalytic activity:S-adenosyl-L-methionine + histone L-lysine = S-adenosyl-L-homocysteine + histone N(6)-methyl-L-lysine.,caution:This protein was first named MLL2 by PubMed:10637508 and PubMed:10409430. MLL2 corresponds to another protein located on chromosome 12 (see AC O14686).,disease:Often amplified in pancreatic carcinomas.,function:Histone methyltransferase. Methylates 'Lys-4' of histone H3. H3 'Lys-4' methylation represents a specific tag for epigenetic transcriptional activation.,PTM:Phosphorylated upon DNA damage, probably by ATM or ATR.,similarity:Belongs to the histone-lysine methyltransferase family. TRX/MLL subfamily.,similarity:Contains 1 CXXC-type zinc finger.,similarity:Contains 1 post-SET domain.,similarity:Contains 1 SET domain.,similarity:Contains 3 A.T hook DNA-binding domains.,similarity:Contains 3 PHD-type zinc fingers.,subunit:Component of the MLL3/MLL4 complex, a
Gene Name
WBP7 HRX2 KIAA0304 KMT2B MLL2 MLL4 TRX2
Protein name
Histone-lysine N-methyltransferase MLL4 (EC 2.1.1.43) (Lysine N-methyltransferase 2B) (KMT2B) (Myeloid/lymphoid or mixed-lineage leukemia protein 4) (Trithorax homolog 2) (WW domain-binding protein 7)
Fields
>>Lysine degradation;>>Metabolic pathways
Human protein sequence Database
Q9UMN6
Mouse protein sequence database
O08550
Rat protein sequence database
Cellular localization
Nucleus .
Tissue expression
Widely expressed. Highest levels in testis. Also found in brain with higher expression in the cerebellum than in any other region, bone marrow, heart, muscle, kidney, placenta, spleen, thymus, prostate, ovary, intestine, colon, peripheral blood lymphocytes and pancreas. Often amplified in pancreatic carcinomas.
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