Molecular weight (DA)
75kD
Immunogen
Synthesized peptide derived from human protein . at AA range: 540-620
Specificity
CO9A2 Polyclonal Antibody detects endogenous levels of protein.
Formulation
Liquid in PBS containing 50% glycerol, and 0.02% sodium azide.
Dilution rate
WB 1:500-2000 ELISA 1:5000-20000
Purification process (Immunogen)
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Background
This gene encodes one of the three alpha chains of type IX collagen, the major collagen component of hyaline cartilage. Type IX collagen, a heterotrimeric molecule, is usually found in tissues containing type II collagen, a fibrillar collagen. This chain is unusual in that, unlike the other two type IX alpha chains, it contains a covalently attached glycosaminoglycan side chain. Mutations in this gene are associated with multiple epiphyseal dysplasia. [provided by RefSeq, Jul 2008],
Function
disease:Defects in COL9A2 are the cause of multiple epiphyseal dysplasia type 2 (EDM2) [MIM:600204]. EDM is a generalized skeletal dysplasia associated with significant morbidity. Joint pain, joint deformity, waddling gait, and short stature are the main clinical signs and symptoms. EDM is broadly categorized into the more severe Fairbank and the milder Ribbing types. EDM2 inheritance is autosomal dominant.,disease:Defects in COL9A2 may be a cause of susceptibility to intervertebral disc disease (IDD) [MIM:603932]. IDD is one of the most common musculo-skeletal disorders.,function:Structural component of hyaline cartilage and vitreous of the eye.,PTM:Covalently linked to the telopeptides of type II collagen by lysine-derived cross-links.,PTM:Prolines at the third position of the tripeptide repeating unit (G-X-Y) are hydroxylated in some or all of the chains.,similarity:Belongs to the fib
Protein name
Collagen alpha-2(IX) chain
Fields
>>PI3K-Akt signaling pathway;>>Focal adhesion;>>ECM-receptor interaction;>>Protein digestion and absorption;>>Human papillomavirus infection
Human protein sequence Database
Q14055
Mouse protein sequence database
Q07643
Rat protein sequence database
Cellular localization
Secreted, extracellular space, extracellular matrix .
Tissue expression
Cartilage,Foreskin,
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