Molecular weight (DA)
48kD
Immunogen
Synthesized peptide derived from human protein . at AA range: 270-350
Specificity
CRLF3 Polyclonal Antibody detects endogenous levels of protein.
Formulation
Liquid in PBS containing 50% glycerol, and 0.02% sodium azide.
Dilution rate
WB 1:500-2000 ELISA 1:5000-20000
Purification process (Immunogen)
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Background
This gene encodes a cytokine receptor-like factor that may negatively regulate cell cycle progression at the G0/G1 phase. Studies of the related rat protein suggest that it may regulate neuronal morphology and synaptic vesicle biogenesis. This gene is one of several genes located in the neurofibromatosis type I tumor suppressor region on the q arm of chromosome 17, a region that is subject to microdeletions, duplications, chromosomal breaks and rearrangements. Alternative splicing of this gene results in multiple transcript variants. Related pseudogenes have been identified on chromosomes 2 and 5. [provided by RefSeq, Aug 2012],
Function
similarity:Belongs to the cytokine receptor-like factor 3 family.,similarity:Contains 1 fibronectin type-III domain.,tissue specificity:Expressed in skin and squamous cell carcinoma (SCC) and in lesion actinic keratosis (AK).,
Gene Name
CRLF3 CREME9 CYTOR4 P48
Protein name
Cytokine receptor-like factor 3 (Cytokine receptor-like molecule 9) (CREME-9) (Cytokine receptor-related protein 4) (Type I cytokine receptor-like factor p48)
Human protein sequence Database
Q8IUI8
Mouse protein sequence database
Q9Z2L7
Rat protein sequence database
Cellular localization
Cytoplasm . The EGFP- and MYC-tagged protein has been shown to be cytoplasmic. .
Tissue expression
Expressed in several embryonic and adult tissues, including adult and fetal brain, liver, spleen and pancreas. Expressed in adult, but not fetal kidney. Expressed in skin and squamous cell carcinoma (SCC) and in several other cancer types. Also detected in lesion actinic keratosis (AK).
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