Molecular weight (DA)
504kD
Immunogen
Synthesized peptide derived from human protein . at AA range: 1140-1220
Specificity
FAT1 Polyclonal Antibody detects endogenous levels of protein.
Formulation
Liquid in PBS containing 50% glycerol, and 0.02% sodium azide.
Dilution rate
IHC-p 1:50-300. IF 1:50-200
Purification process (Immunogen)
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Background
This gene is an ortholog of the Drosophila fat gene, which encodes a tumor suppressor essential for controlling cell proliferation during Drosophila development. The gene product is a member of the cadherin superfamily, a group of integral membrane proteins characterized by the presence of cadherin-type repeats. In addition to containing 34 tandem cadherin-type repeats, the gene product has five epidermal growth factor (EGF)-like repeats and one laminin A-G domain. This gene is expressed at high levels in a number of fetal epithelia. Its product probably functions as an adhesion molecule and/or signaling receptor, and is likely to be important in developmental processes and cell communication. Transcript variants derived from alternative splicing and/or alternative promoter usage exist, but they have not been fully described. [provided by RefSeq, Jul 2008],
Function
function:Could function as a cell-adhesion protein.,PTM:Phosphorylated upon DNA damage, probably by ATM or ATR.,similarity:Contains 1 laminin G-like domain.,similarity:Contains 34 cadherin domains.,similarity:Contains 5 EGF-like domains.,tissue specificity:Expressed in many epithelial and some endothelial and smooth muscle cells.,
Protein name
Protocadherin Fat 1 (Cadherin family member 7) (Cadherin-related tumor suppressor homolog) (Protein fat homolog) [Cleaved into: Protocadherin Fat 1, nuclear form]
Human protein sequence Database
Q14517
Mouse protein sequence database
Rat protein sequence database
Cellular localization
[Protocadherin Fat 1]: Cell membrane ; Single-pass type I membrane protein .; [Protocadherin Fat 1, nuclear form]: Nucleus .
Tissue expression
Expressed in many epithelial and some endothelial and smooth muscle cells.
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