Molecular weight (DA)
77kD
Immunogen
Synthesized peptide derived from human protein . at AA range: 40-120
Specificity
ACSA Polyclonal Antibody detects endogenous levels of protein.
Formulation
Liquid in PBS containing 50% glycerol, and 0.02% sodium azide.
Dilution rate
WB 1:500-2000 ELISA 1:5000-20000
Purification process (Immunogen)
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Background
This gene encodes a cytosolic enzyme that catalyzes the activation of acetate for use in lipid synthesis and energy generation. The protein acts as a monomer and produces acetyl-CoA from acetate in a reaction that requires ATP. Expression of this gene is regulated by sterol regulatory element-binding proteins, transcription factors that activate genes required for the synthesis of cholesterol and unsaturated fatty acids. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2009],
Function
catalytic activity:ATP + acetate + CoA = AMP + diphosphate + acetyl-CoA.,function:Activates acetate so that it can be used for lipid synthesis or for energy generation.,similarity:Belongs to the ATP-dependent AMP-binding enzyme family.,subunit:Monomer.,
Protein name
Acetyl-coenzyme A synthetase, cytoplasmic (EC 6.2.1.1) (Acetate--CoA ligase) (Acetyl-CoA synthetase) (ACS) (AceCS) (Acyl-CoA synthetase short-chain family member 2) (Acyl-activating enzyme)
Fields
>>Glycolysis / Gluconeogenesis;>>Pyruvate metabolism;>>Glyoxylate and dicarboxylate metabolism;>>Propanoate metabolism;>>Metabolic pathways;>>Carbon metabolism
Human protein sequence Database
Q9NR19
Mouse protein sequence database
Q9QXG4
Rat protein sequence database
Cellular localization
Cytoplasm, cytosol .
Tissue expression
Blood,Melanoma,Muscle,Platelet,Skin,Tongue,
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