Molecular weight (DA)
56kD
Immunogen
Synthesized peptide derived from human protein . at AA range: 290-370
Specificity
AL1A3 Polyclonal Antibody detects endogenous levels of protein.
Formulation
Liquid in PBS containing 50% glycerol, and 0.02% sodium azide.
Dilution rate
WB 1:500-2000 ELISA 1:5000-20000
Purification process (Immunogen)
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Background
This gene encodes an aldehyde dehydrogenase enzyme that uses retinal as a substrate. Mutations in this gene have been associated with microphthalmia, isolated 8, and expression changes have also been detected in tumor cells. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jun 2014],
Function
catalytic activity:An aldehyde + NAD(P)(+) + H(2)O = an acid + NAD(P)H.,function:Recognizes as substrates free retinal and cellular retinol-binding protein-bound retinal. Seems to be the key enzyme in the formation of an RA gradient along the dorso-ventral axis during the early eye development and also in the development of the olfactory system.,pathway:Cofactor metabolism; retinol metabolism.,similarity:Belongs to the aldehyde dehydrogenase family.,tissue specificity:Expressed at low levels in many tissues and at higher levels in salivary gland, stomach, and kidney.,
Protein name
Aldehyde dehydrogenase family 1 member A3 (EC 1.2.1.5) (Aldehyde dehydrogenase 6) (Retinaldehyde dehydrogenase 3) (RALDH-3) (RalDH3)
Fields
>>Retinol metabolism;>>Metabolic pathways
Human protein sequence Database
P47895
Mouse protein sequence database
Q9JHW9
Rat protein sequence database
Q8K4D8
Cellular localization
Cytoplasm .
Tissue expression
Expressed at low levels in many tissues and at higher levels in salivary gland, stomach, and kidney.
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