Molecular weight (DA)
33kD
Immunogen
Synthesized peptide derived from human protein . at AA range: 230-310
Specificity
AQP10 Polyclonal Antibody detects endogenous levels of protein.
Formulation
Liquid in PBS containing 50% glycerol, and 0.02% sodium azide.
Dilution rate
WB 1:500-2000 ELISA 1:5000-20000
Purification process (Immunogen)
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Background
This gene encodes a member of the aquaglyceroporin family of integral membrane proteins. Members of this family function as water-permeable channels in the epithelia of organs that absorb and excrete water. This protein was shown to function as a water-selective channel, and could also permeate neutral solutes such as glycerol and urea. [provided by RefSeq, Jul 2008],
Function
domain:Aquaporins contain two tandem repeats each containing three membrane-spanning domains and a pore-forming loop with the signature motif Asn-Pro-Ala (NPA).,function:Forms a water channel. Not permeable to urea and glycerol. May contribute to water transport in the upper portion of small intestine.,similarity:Belongs to the MIP/aquaporin (TC 1.A.8) family.,tissue specificity:Expressed exclusively in duodenum and jejunum. Highest expression in absorptive epithelial cells at the tips of villi in the jejunum.,
Protein name
Aquaporin-10 (AQP-10) (Aquaglyceroporin-10) (Small intestine aquaporin)
Human protein sequence Database
Q96PS8
Mouse protein sequence database
Rat protein sequence database
Cellular localization
Apical cell membrane ; Multi-pass membrane protein . Cell membrane ; Multi-pass membrane protein . Lipid droplet . Detected around lipid droplets. .
Tissue expression
Detected in epithelial cells on villi in the ileum, and also in stomach, jejunum, colon, rectum, white adipose tissue and placenta (at protein level) (PubMed:15221416, PubMed:23382902). Expressed in duodenum and jejunum. Highest expression in absorptive epithelial cells at the tips of villi in the jejunum (PubMed:11573934, PubMed:12084581). Detected in subcutaneous adipose tissue (PubMed:23382902).
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