Molecular weight (DA)
28kD
Immunogen
Synthesized peptide derived from human protein . at AA range: 70-150
Specificity
AQP8 Polyclonal Antibody detects endogenous levels of protein.
Formulation
Liquid in PBS containing 50% glycerol, and 0.02% sodium azide.
Dilution rate
WB 1:500-2000 ELISA 1:5000-20000
Purification process (Immunogen)
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Background
Aquaporin 8 (AQP8) is a water channel protein. Aquaporins are a family of small integral membrane proteins related to the major intrinsic protein (MIP or AQP0). Aquaporin 8 mRNA is found in pancreas and colon but not other tissues. [provided by RefSeq, Jul 2008],
Function
domain:Aquaporins contain two tandem repeats each containing three membrane-spanning domains and a pore-forming loop with the signature motif Asn-Pro-Ala (NPA).,function:Forms a water-specific channel; mercury-sensitive. Not permeable to glycerol or urea.,similarity:Belongs to the MIP/aquaporin (TC 1.A.8) family.,tissue specificity:Expressed only in pancreas and colon.,
Protein name
Aquaporin-8 (AQP-8)
Human protein sequence Database
O94778
Mouse protein sequence database
P56404
Rat protein sequence database
P56405
Cellular localization
Mitochondrion membrane ; Multi-pass membrane protein .
Tissue expression
Detected in the sperm midpiece (at protein level) (PubMed:28042826). Expressed only in pancreas and colon.
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