Molecular weight (DA)
52kD
Immunogen
Synthesized peptide derived from human protein . at AA range: 10-90
Specificity
ATX10 Polyclonal Antibody detects endogenous levels of protein.
Formulation
Liquid in PBS containing 50% glycerol, and 0.02% sodium azide.
Dilution rate
WB 1:500-2000 ELISA 1:5000-20000
Purification process (Immunogen)
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Background
This gene encodes a protein that may function in neuron survival, neuron differentiation, and neuritogenesis. These roles may be carried out via activation of the mitogen-activated protein kinase cascade. Expansion of an ATTCT repeat from 9-32 copies to 800-4500 copies in an intronic region of this locus has been associated with spinocerebellar ataxia, type 10. Alternatively spliced transcript variants have been described.[provided by RefSeq, Jul 2016],
Function
disease:Defects in ATXN10 are the cause of spinocerebellar ataxia type 10 (SCA10) [MIM:603516]. Spinocerebellar ataxia is a clinically and genetically heterogeneous group of cerebellar disorders. Patients show progressive incoordination of gait and often poor coordination of hands, speech and eye movements, due to degeneration of the cerebellum with variable involvement of the brainstem and spinal cord. SCA10 is an autosomal dominant cerebellar ataxia (ADCA).,similarity:Belongs to the ataxin-10 family.,
Protein name
Ataxin-10 (Brain protein E46 homolog) (Spinocerebellar ataxia type 10 protein)
Fields
>>Spinocerebellar ataxia
Human protein sequence Database
Q9UBB4
Mouse protein sequence database
P28658
Rat protein sequence database
Q9ER24
Cellular localization
Cytoplasm, perinuclear region .
Tissue expression
Expressed in the central nervous system.
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