Molecular weight (DA)
169kD
Immunogen
Synthesized peptide derived from human protein . at AA range: 1100-1180
Specificity
ABCAA Polyclonal Antibody detects endogenous levels of protein.
Formulation
Liquid in PBS containing 50% glycerol, and 0.02% sodium azide.
Dilution rate
WB 1:500-2000 ELISA 1:5000-20000
Purification process (Immunogen)
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Background
The membrane-associated protein encoded by this gene is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intracellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, and White). This encoded protein is a member of the ABC1 subfamily. Members of the ABC1 subfamily comprise the only major ABC subfamily found exclusively in multicellular eukaryotes. This gene is clustered among 4 other ABC1 family members on 17q24, but neither the substrate nor the function of this gene is known. [provided by RefSeq, Jul 2008],
Function
function:Probable transporter which may play a role in macrophage lipid homeostasis.,induction:Down-regulated by cholesterol loading of macrophages.,similarity:Belongs to the ABC transporter family. ABCA subfamily.,similarity:Contains 2 ABC transporter domains.,tissue specificity:Widely expressed. Highly expressed in skeletal muscle, heart, brain and gastrointestinal tract.,
Protein name
ATP-binding cassette sub-family A member 10
Fields
>>ABC transporters
Human protein sequence Database
Q8WWZ4
Mouse protein sequence database
Rat protein sequence database
Cellular localization
Membrane ; Multi-pass membrane protein .
Tissue expression
Widely expressed. Highly expressed in skeletal muscle, heart, brain and gastrointestinal tract.
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