Molecular weight (DA)
36kD
Immunogen
Synthesized peptide derived from human protein . at AA range: 50-130
Specificity
B3GT6 Polyclonal Antibody detects endogenous levels of protein.
Formulation
Liquid in PBS containing 50% glycerol, and 0.02% sodium azide.
Dilution rate
WB 1:500-2000 ELISA 1:5000-20000
Purification process (Immunogen)
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Background
The enzyme encoded by this intronless gene is a beta-1,3-galactosyltransferase found in the medial Golgi apparatus, where it catalyzes the transfer of galactose from UDP-galactose to substrates containing a terminal beta-linked galactose moiety. The encoded enzyme has a particular affinity for galactose-beta-1,4-xylose found in the linker region of glycosamines. This enzyme is required for glycosaminoglycan synthesis. [provided by RefSeq, Jun 2013],
Function
catalytic activity:UDP-galactose + 4-beta-D-galactosyl-O-beta-D-xylosylprotein = UDP + 3-beta-D-galactosyl-4-beta-D-galactosyl-O-beta-D-xylosylprotein.,caution:PubMed:9892646 describes the wrong protein; the cDNAs used had been switched inadvertently.,cofactor:Manganese.,function:Beta-1,3-galactosyltransferase that transfers galactose from UDP-galactose to substrates with a terminal beta-linked galactose residue. Has a preference for galactose-beta-1,4-xylose that is found in the linker region of glycosaminoglycans, such as heparan sulfate and chondroitin sulfate. Has no activity towards substrates with terminal glucosamine or galactosamine residues.,online information:Beta-1,3-galactosyltransferase 6,online information:GlycoGene database,pathway:Glycan metabolism; chondroitin sulfate biosynthesis.,pathway:Glycan metabolism; heparan sulfate biosynthesis.,similarity:Belongs to the glycosy
Protein name
Beta-1,3-galactosyltransferase 6 (Beta-1,3-GalTase 6) (Beta3Gal-T6) (Beta3GalT6) (EC 2.4.1.134) (GAG GalTII) (Galactosyltransferase II) (Galactosylxylosylprotein 3-beta-galactosyltransferase) (UDP-Gal
Fields
>>Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate;>>Glycosaminoglycan biosynthesis - heparan sulfate / heparin;>>Metabolic pathways
Human protein sequence Database
Q96L58
Mouse protein sequence database
Q91Z92
Rat protein sequence database
Cellular localization
Golgi apparatus, Golgi stack membrane ; Single-pass type II membrane protein .
Tissue expression
Ubiquitous.
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