Molecular weight (DA)
42kD
Immunogen
Synthesized peptide derived from part region of human protein
Specificity
B4GT6 Polyclonal Antibody detects endogenous levels of protein.
Formulation
Liquid in PBS containing 50% glycerol, and 0.02% sodium azide.
Dilution rate
WB 1:500-2000 ELISA 1:5000-20000
Purification process (Immunogen)
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Background
This gene is one of seven beta-1,4-galactosyltransferase (beta4GalT) genes. They encode type II membrane-bound glycoproteins that appear to have exclusive specificity for the donor substrate UDP-galactose; all transfer galactose in a beta1,4 linkage to similar acceptor sugars: GlcNAc, Glc, and Xyl. Each beta4GalT has a distinct function in the biosynthesis of different glycoconjugates and saccharide structures. As type II membrane proteins, they have an N-terminal hydrophobic signal sequence that directs the protein to the Golgi apparatus and which then remains uncleaved to function as a transmembrane anchor. By sequence similarity, the beta4GalTs form four groups: beta4GalT1 and beta4GalT2, beta4GalT3 and beta4GalT4, beta4GalT5 and beta4GalT6, and beta4GalT7. The enzyme encoded by this gene is a lactosylceramide synthase important for glycolipid biosynthesis. [provided by RefSeq, Ju
Function
catalytic activity:UDP-galactose + glucosylceramide = UDP + lactosylceramide.,cofactor:Manganese or magnesium or calcium.,enzyme regulation:Inhibited by EDTA.,function:Required for the biosynthesis of glycosphingolipids.,online information:Beta-1,4-galactosyltransferase 6,online information:GlycoGene database,pathway:Protein modification; protein glycosylation.,similarity:Belongs to the glycosyltransferase 7 family.,subcellular location:Trans cisternae of Golgi stack.,tissue specificity:High expression in brain and adrenal gland, lower in liver, lung, colon and peripheral white blood cells.,
Protein name
Beta-1,4-galactosyltransferase 6 (Beta-1,4-GalTase 6) (Beta4Gal-T6) (b4Gal-T6) (EC 2.4.1.-) (UDP-Gal:beta-GlcNAc beta-1,4-galactosyltransferase 6) (UDP-galactose:beta-N-acetylglucosamine beta-1,4-gala
Fields
>>Sphingolipid metabolism;>>Metabolic pathways
Human protein sequence Database
Q9UBX8
Mouse protein sequence database
Q9WVK5
Rat protein sequence database
O88419
Cellular localization
Golgi apparatus, Golgi stack membrane ; Single-pass type II membrane protein. Trans cisternae of Golgi stack. .
Tissue expression
High expression in brain and adrenal gland, lower in liver, lung, colon and peripheral white blood cells.
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