Molecular weight (DA)
35kD
Immunogen
Synthesized peptide derived from part region of human protein
Specificity
UCP5 Polyclonal Antibody detects endogenous levels of protein.
Formulation
Liquid in PBS containing 50% glycerol, and 0.02% sodium azide.
Dilution rate
WB 1:500-2000 ELISA 1:5000-20000
Purification process (Immunogen)
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Background
Mitochondrial uncoupling proteins (UCP) are members of the larger family of mitochondrial anion carrier proteins (MACP). Uncoupling proteins separate oxidative phosphorylation from ATP synthesis with energy dissipated as heat, also referred to as the mitochondrial proton leak. Uncoupling proteins facilitate the transfer of anions from the inner to the outer mitochondrial membrane and the return transfer of protons from the outer to the inner mitochondrial membrane. They also reduce the mitochondrial membrane potential in mammalian cells. This gene is widely expressed in many tissues with the greatest abundance in brain and testis. Alternative splicing results in multiple transcript variants. A pseudogene of this gene has been defined on chromosome 4. [provided by RefSeq, Aug 2013],
Function
function:Participates in the mitochondrial proton leak measured in brain mitochondria.,similarity:Belongs to the mitochondrial carrier family.,similarity:Contains 3 Solcar repeats.,tissue specificity:Mainly expressed in brain. Some expression in testis and pituitary.,
Gene Name
SLC25A14 BMCP1 UCP5 UNQ791/PRO1682
Protein name
Brain mitochondrial carrier protein 1 (BMCP-1) (Mitochondrial uncoupling protein 5) (UCP 5) (Solute carrier family 25 member 14)
Human protein sequence Database
O95258
Mouse protein sequence database
Q9Z2B2
Rat protein sequence database
Cellular localization
Mitochondrion inner membrane ; Multi-pass membrane protein .
Tissue expression
Mainly expressed in brain. Some expression in testis and pituitary.
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