Molecular weight (DA)
77kD
Immunogen
Synthesized peptide derived from part region of human protein
Specificity
CEP63 Polyclonal Antibody detects endogenous levels of protein.
Formulation
Liquid in PBS containing 50% glycerol, and 0.02% sodium azide.
Dilution rate
WB 1:500-2000 ELISA 1:5000-20000
Purification process (Immunogen)
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Background
This gene encodes a protein with six coiled-coil domains. The protein is localized to the centrosome, a non-membraneous organelle that functions as the major microtubule-organizing center in animal cells. Several alternatively spliced transcript variants have been found, but their biological validity has not been determined. [provided by RefSeq, Jul 2008],
Function
cell cycle checkpoint, DNA damage checkpoint, M phase of mitotic cell cycle, microtubule cytoskeleton organization,mitotic cell cycle, M phase, nuclear division, response to DNA damage stimulus, cytoskeleton organization, microtubule-based process, cell cycle, spindle organization, mitosis, intracellular signaling cascade, cell cycle process, cell cycle phase, DNA integrity checkpoint, cellular response to stress, DNA damage response, signal transduction, organelle fission, spindle assembly, cell division, regulation of cell cycle,
Protein name
Centrosomal protein of 63 kDa (Cep63)
Human protein sequence Database
Q96MT8
Mouse protein sequence database
Q3UPP8
Rat protein sequence database
Q4KLY0
Cellular localization
Cytoplasm, cytoskeleton, microtubule organizing center, centrosome . Cytoplasm, cytoskeleton, microtubule organizing center, centrosome, centriole . Cytoplasm, cytoskeleton, microtubule organizing center, centrosome, centriolar satellite . Colocalizes with CDK5RAP2, CEP152 and WDR62 in a discrete ring around the proximal end of the parental centriole. At this site, a cohesive structure is predicted to engage parental centrioles and procentrioles. .
Tissue expression
Pancreas,Placenta,Teratocarcinoma,
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