Molecular weight (DA)
204kD
Immunogen
Synthesized peptide derived from part region of human protein
Specificity
MYCPP Polyclonal Antibody detects endogenous levels of protein.
Formulation
Liquid in PBS containing 50% glycerol, and 0.02% sodium azide.
Dilution rate
WB 1:500-2000 ELISA 1:5000-20000
Purification process (Immunogen)
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Background
This gene encodes a DENN domain-containing protein that may function as a guanine nucleotide exchange factor that specifically activates ras-related protein Rab-10. This protein also contains a interferon stimulated response element-binding domain and may be involved in regulating the v-myc avian myelocytomatosis viral (MYC) oncogene. Alternate splicing results in multiple transcript variants. A pseudogene of this gene is found on chromosome 8. [provided by RefSeq, Mar 2016],
Function
developmental stage:Highly expressed in fetal liver.,function:Binds to ISRE-like element (interferon-stimulated response element) of MYC P2 promoter.,induction:Induced by serum in low-passage fibroblasts.,similarity:Contains 1 dDENN domain.,similarity:Contains 1 DENN domain.,similarity:Contains 1 uDENN domain.,similarity:Contains 2 PPR (pentatricopeptide) repeats.,tissue specificity:Expressed ubiquitously. Highest expression in bone marrow, medium in peripheral blood lymphocytes and lowest in spleen. In brain, breast, and prostate, higher expression was seen in normal cells than in tumor cells. Expression is regulated in a growth- and cell cycle-dependent manner.,
Gene Name
DENND4A IRLB MYCPBP
Protein name
C-myc promoter-binding protein (DENN domain-containing protein 4A)
Human protein sequence Database
Q7Z401
Mouse protein sequence database
Rat protein sequence database
Cellular localization
Nucleus .
Tissue expression
Expressed ubiquitously. Highest expression in bone marrow, medium in peripheral blood lymphocytes and lowest in spleen. In brain, breast, and prostate, higher expression was seen in normal cells than in tumor cells. Expression is regulated in a growth- and cell cycle-dependent manner.
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