Molecular weight (DA)
70kD
Immunogen
Synthesized peptide derived from part region of human protein
Specificity
DC1I2 Polyclonal Antibody detects endogenous levels of protein.
Formulation
Liquid in PBS containing 50% glycerol, and 0.02% sodium azide.
Dilution rate
WB 1:500-2000 ELISA 1:5000-20000
Purification process (Immunogen)
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Background
This gene encodes a member of the dynein intermediate chain family. The encoded protein is a non-catalytic component of the cytoplasmic dynein 1 complex, which acts as a retrograde microtubule motor to transport organelles and vesicles. A pseudogene of this gene is located on chromosome 10. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Nov 2012],
Function
function:The intermediate chains seem to help dynein bind to dynactin 150 kDa component.,PTM:Phosphorylated upon DNA damage, probably by ATM or ATR.,sequence caution:Unlikely isoform. Several sequence problems.,similarity:Belongs to the dynein intermediate chain family.,similarity:Contains 7 WD repeats.,subunit:Consists of at least two heavy chains and a number of intermediate and light chains.,
Gene Name
DYNC1I2 DNCI2 DNCIC2
Protein name
Cytoplasmic dynein 1 intermediate chain 2 (Cytoplasmic dynein intermediate chain 2) (Dynein intermediate chain 2, cytosolic) (DH IC-2)
Fields
>>Phagosome;>>Vasopressin-regulated water reabsorption;>>Salmonella infection
Human protein sequence Database
Q13409
Mouse protein sequence database
O88487
Rat protein sequence database
Q62871
Cellular localization
Cytoplasm, cytoskeleton . Cytoplasm . Detected in the cytoplasm of pachytene spermatocytes. Localizes to the manchette in elongating spermatids. .
Tissue expression
Brain,Cajal-Retzius cell,Endometrium,Epithelium,Kidney,Skin
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