Molecular weight (DA)
89kD
Immunogen
Synthesized peptide derived from part region of human protein
Specificity
DLG3 Polyclonal Antibody detects endogenous levels of protein.
Formulation
Liquid in PBS containing 50% glycerol, and 0.02% sodium azide.
Dilution rate
WB 1:500-2000 ELISA 1:5000-20000
Purification process (Immunogen)
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Background
This gene encodes a member of the membrane-associated guanylate kinase protein family. The encoded protein may play a role in clustering of NMDA receptors at excitatory synapses. It may also negatively regulate cell proliferation through interaction with the C-terminal region of the adenomatosis polyposis coli tumor suppressor protein. Mutations in this gene have been associated with X-linked mental retardation. Alternatively spliced transcript variants have been described. [provided by RefSeq, Oct 2009],
Function
alternative products:Named isoforms=2,disease:Defects in DLG3 are the cause of mental retardation X-linked type 90 (MRX90) [MIM:300189]. Mental retardation is characterized by significantly sub-average general intellectual functioning associated with impairments in adaptative behavior and manifested during the developmental period. Non-syndromic mental retardation patients do not manifest other clinical signs.,function:Required for learning most likely through its role in synaptic plasticity following NMDA receptor signaling.,similarity:Belongs to the MAGUK family.,similarity:Contains 1 guanylate kinase-like domain.,similarity:Contains 1 PDZ (DHR) domain.,similarity:Contains 1 SH3 domain.,similarity:Contains 3 PDZ (DHR) domains.,subunit:Interacts through its PDZ domains with GRIN2B and SYNGAP1. Interacts through its guanylate kinase-like domain with DLGAP1, DLGAP2, DLGAP3 and DLGAP4 (By
Protein name
Disks large homolog 3 (Neuroendocrine-DLG) (Synapse-associated protein 102) (SAP-102) (SAP102) (XLMR)
Fields
>>Hippo signaling pathway;>>Tight junction;>>Human papillomavirus infection
Human protein sequence Database
Q92796
Mouse protein sequence database
P70175
Rat protein sequence database
Q62936
Cellular localization
extracellular space,cytoplasm,plasma membrane,bicellular tight junction,ionotropic glutamate receptor complex,postsynaptic density,basolateral plasma membrane,growth cone,AMPA glutamate receptor complex,neuronal cell body,d
Tissue expression
Brain,Fetal brain,Thymus,Trachea,
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