Molecular weight (DA)
60kD
Immunogen
Synthesized peptide derived from part region of human protein
Specificity
CDT1 Polyclonal Antibody detects endogenous levels of protein.
Formulation
Liquid in PBS containing 50% glycerol, and 0.02% sodium azide.
Dilution rate
WB 1:500-2000 ELISA 1:5000-20000
Purification process (Immunogen)
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Background
The protein encoded by this gene is involved in the formation of the pre-replication complex that is necessary for DNA replication. The encoded protein can bind geminin, which prevents replication and may function to prevent this protein from initiating replication at inappropriate origins. Phosphorylation of this protein by cyclin A-dependent kinases results in degradation of the protein. [provided by RefSeq, Mar 2011],
Function
developmental stage:Present during G1 and early S phase of the cell cycle. Degraded during the late S, G2, and M phases.,function:Cooperates with CDC6 to promote the loading of the mini-chromosome maintenance complex onto chromatin to form the pre-replication complex necessary to initiate DNA replication. Binds DNA in a sequence-, strand-, and conformation-independent manner. Potential oncogene.,PTM:Phosphorylated by cyclin A-dependent kinases which results in the binding of CDT1 to the F-box protein SKP2 and subsequent degradation. Binding to GMNN is not affected by phosphorylation.,PTM:Ubiquitinated, leading to its subsequent degradation. The interaction with GMNN protects it against ubiquitination.,similarity:Belongs to the Cdt1 family.,subunit:Interaction with GMNN inhibits both binding of the MCM complex to origins of replication and DNA-binding activity.,
Protein name
DNA replication factor Cdt1 (Double parked homolog) (DUP)
Human protein sequence Database
Q9H211
Mouse protein sequence database
Q8R4E9
Rat protein sequence database
Cellular localization
Nucleus . Chromosome, centromere, kinetochore . Transiently localizes to kinetochores during prometaphase and metaphase. .
Tissue expression
Brain,Cervix,Epithelium,Eye,Kidney,Liver,Uterus,
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