Molecular weight (DA)
19kD
Immunogen
Synthesized peptide derived from part region of human protein
Specificity
RNF5 Polyclonal Antibody detects endogenous levels of protein.
Formulation
Liquid in PBS containing 50% glycerol, and 0.02% sodium azide.
Dilution rate
WB 1:500-2000 ELISA 1:5000-20000
Purification process (Immunogen)
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Background
The protein encoded by this gene contains a RING finger, which is a motif known to be involved in protein-protein interactions. This protein is a membrane-bound ubiquitin ligase. It can regulate cell motility by targeting paxillin ubiquitination and altering the distribution and localization of paxillin in cytoplasm and cell focal adhesions. [provided by RefSeq, Jul 2008],
Function
function:Has E2-dependent E3 ubiquitin-protein ligase activity. May function together with E2 ubiquitin-conjugating enzymes UBE2D1/UBCH5A and UBE2D2/UBC4. Mediates ubiquitination of PXN/paxillin and Salmonella type III secreted protein sopA. May be involved in regulation of cell motility and localization of PXN/paxillin.,similarity:Contains 1 RING-type zinc finger.,subcellular location:Predominantly located in the plasma membrane, with some localization occurring within cytoplasmic organelles.,subunit:Interacts with PXN. Interacts with Salmonella typhimurium sopA. Interacts with JAMP.,tissue specificity:Widely expressed.,
Gene Name
RNF5 G16 NG2 RMA1
Protein name
E3 ubiquitin-protein ligase RNF5 (EC 6.3.2.-) (Protein G16) (RING finger protein 5) (Ram1 homolog) (HsRma1)
Fields
>>Protein processing in endoplasmic reticulum
Human protein sequence Database
Q99942
Mouse protein sequence database
O35445
Rat protein sequence database
Q5M807
Cellular localization
Cell membrane ; Multi-pass membrane protein . Mitochondrion membrane ; Multi-pass membrane protein . Endoplasmic reticulum membrane ; Multi-pass membrane protein . Predominantly located in the plasma membrane, with some localization occurring within cytoplasmic organelles. .
Tissue expression
Widely expressed.
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