Molecular weight (DA)
102kD
Immunogen
Synthesized peptide derived from part region of human protein
Specificity
EDEM3 Polyclonal Antibody detects endogenous levels of protein.
Formulation
Liquid in PBS containing 50% glycerol, and 0.02% sodium azide.
Dilution rate
WB 1:500-2000 ELISA 1:5000-20000
Purification process (Immunogen)
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Background
Quality control in the endoplasmic reticulum (ER) ensures that only properly folded proteins are retained in the cell through recognition and degradation of misfolded or unassembled proteins. EDEM3 belongs to a group of proteins that accelerate degradation of misfolded glycoproteins in the ER (Hirao et al., 2006 [PubMed 16431915]).[supplied by OMIM, Mar 2008],
Function
domain:Contains a protease-associated domain (PA) of unknown function.,function:Involved in endoplasmic reticulum-associated degradation (ERAD). Accelerates the glycoprotein ERAD by proteasomes. This process depends on mannose-trimming from the N-glycans. Seems to have alpha 1,2-mannosidase activity.,PTM:N-glycosylated.,similarity:Belongs to the glycosyl hydrolase 47 family.,similarity:Contains 1 PA (protease associated) domain.,
Protein name
ER degradation-enhancing alpha-mannosidase-like 3
Fields
>>Protein processing in endoplasmic reticulum
Human protein sequence Database
Q9BZQ6
Mouse protein sequence database
Q2HXL6
Rat protein sequence database
Cellular localization
Endoplasmic reticulum lumen .
Tissue expression
Brain,Liver,Lung,Placenta,Testis,Whole embr
Contract Us
Follow Us
Location： 
Specification
成功添加到购物车