Molecular weight (DA)
94kD
Immunogen
Synthesized peptide derived from part region of human protein
Specificity
AGO3 Polyclonal Antibody detects endogenous levels of protein.
Formulation
Liquid in PBS containing 50% glycerol, and 0.02% sodium azide.
Dilution rate
WB 1:500-2000 ELISA 1:5000-20000
Purification process (Immunogen)
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Background
This gene encodes a member of the Argonaute family of proteins which play a role in RNA interference. The encoded protein is highly basic, contains a PAZ domain and a PIWI domain, and may play a role in short-interfering-RNA-mediated gene silencing. This gene is located on chromosome 1 in a tandem cluster of closely related family members including argonaute 4 and eukaryotic translation initiation factor 2C, 1. Two transcript variants encoding distinct isoforms have been identified for this gene. [provided by RefSeq, Jul 2008],
Function
function:Required for RNA-mediated gene silencing (RNAi). Binds to short RNAs such as microRNAs (miRNAs) and represses the translation of mRNAs which are complementary to them. Lacks endonuclease activity and does not appear to cleave target mRNAs.,similarity:Belongs to the argonaute family. Ago subfamily.,similarity:Contains 1 PAZ domain.,similarity:Contains 1 Piwi domain.,subunit:Interacts with EIF4B, IMP8, PRMT5 and TNRC6B.,
Protein name
Protein argonaute-3 (Argonaute3) (hAgo3) (Eukaryotic translation initiation factor 2C 3) (eIF-2C 3) (eIF2C 3)
Human protein sequence Database
Q9H9G7
Mouse protein sequence database
Q8CJF9
Rat protein sequence database
Cellular localization
Cytoplasm, P-body .
Tissue expression
Placenta,Testis,
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