Molecular weight (DA)
40kD
Immunogen
Synthesized peptide derived from part region of human protein
Specificity
GMDS Polyclonal Antibody detects endogenous levels of protein.
Formulation
Liquid in PBS containing 50% glycerol, and 0.02% sodium azide.
Dilution rate
WB 1:500-2000 ELISA 1:5000-20000
Purification process (Immunogen)
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Background
GDP-mannose 4,6-dehydratase (GMD; EC 4.2.1.47) catalyzes the conversion of GDP-mannose to GDP-4-keto-6-deoxymannose, the first step in the synthesis of GDP-fucose from GDP-mannose, using NADP+ as a cofactor. The second and third steps of the pathway are catalyzed by a single enzyme, GDP-keto-6-deoxymannose 3,5-epimerase, 4-reductase, designated FX in humans (MIM 137020).[supplied by OMIM, Aug 2009],
Function
catalytic activity:GDP-mannose = GDP-4-dehydro-6-deoxy-D-mannose + H(2)O.,cofactor:NADP.,function:Conversion of GDP-D-mannose to GDP-4-keto-6-D-deoxymannose.,pathway:Nucleotide-sugar biosynthesis; GDP-L-fucose biosynthesis via de novo pathway; GDP-L-fucose from GDP-D-mannose: step 1/2.,similarity:Belongs to the GDP-mannose 4,6-dehydratase family.,
Protein name
GDP-mannose 4,6 dehydratase (EC 4.2.1.47) (GDP-D-mannose dehydratase) (GMD)
Fields
>>Fructose and mannose metabolism;>>Amino sugar and nucleotide sugar metabolism;>>Metabolic pathways;>>Biosynthesis of nucleotide sugars
Human protein sequence Database
O60547
Mouse protein sequence database
Q8K0C9
Rat protein sequence database
Cellular localization
cytoplasm,cytosol,extracellular exosome,
Tissue expression
Highly expressed in pancreas and small intestine. Expressed in thymus, protstate, colon, heart, placenta, liver and kidney. Expressed at low levels in spleen, testis, brain and lung.
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