Molecular weight (DA)
223kD
Immunogen
Synthesized peptide derived from part region of human protein
Specificity
RGPA1 Polyclonal Antibody detects endogenous levels of protein.
Formulation
Liquid in PBS containing 50% glycerol, and 0.02% sodium azide.
Dilution rate
WB 1:500-2000 ELISA 1:5000-20000
Purification process (Immunogen)
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Background
This gene encodes a major subunit of the RAL-GTPase activating protein. A similar protein in mouse binds E12, a transcriptional regulator of immunoglobulin genes. The mouse protein also functions in skeletal muscle by binding to the regulatory 14-3-3 proteins upon stimulation with insulin or muscle contraction. A pseudogene of this gene has been identified on chromosome 9. [provided by RefSeq, Oct 2016],
Function
regulation of small GTPase mediated signal transduction,
Gene Name
RALGAPA1 GARNL1 KIAA0884 TULIP1
Protein name
Ral GTPase-activating protein subunit alpha-1 (GAP-related-interacting partner to E12) (GRIPE) (GTPase-activating Rap/Ran-GAP domain-like 1) (Tuberin-like protein 1) (p240)
Fields
>>Ras signaling pathway
Human protein sequence Database
Q6GYQ0
Mouse protein sequence database
Q6GYP7
Rat protein sequence database
O55007
Cellular localization
Cytoplasm . Nucleus . Translocated to the nucleus, when associated with TCF3/E12. .
Tissue expression
Widely expressed.
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