Molecular weight (DA)
25kD
Immunogen
Synthesized peptide derived from part region of human protein
Specificity
DIRA3 Polyclonal Antibody detects endogenous levels of protein.
Formulation
Liquid in PBS containing 50% glycerol, and 0.02% sodium azide.
Dilution rate
WB 1:500-2000 ELISA 1:5000-20000
Purification process (Immunogen)
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Background
This gene encodes a member of the ras superfamily. This gene is imprinted gene with monoallelic expression of the paternal allele which is associated with growth suppression. The encoded protein acts as a tumor suppressor whose function is abrogated in many ovarian and breast cancers. This protein may also play a role autophagy in certain cancer cells by regulating the autophagosome initiation complex. [provided by RefSeq, Nov 2015],
Function
online information:NOEY2 entry,similarity:Belongs to the small GTPase superfamily. Di-Ras family.,tissue specificity:Expressed in normal ovarian and breast epithelial cells but not in ovarian and breast cancers.,
Gene Name
DIRAS3 ARHI NOEY2 RHOI
Protein name
GTP-binding protein Di-Ras3 (Distinct subgroup of the Ras family member 3) (Rho-related GTP-binding protein RhoI)
Human protein sequence Database
O95661
Mouse protein sequence database
Rat protein sequence database
Cellular localization
Cell membrane ; Lipid-anchor ; Cytoplasmic side .
Tissue expression
Expressed in normal ovarian and breast epithelial cells but not in ovarian and breast cancers.
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