Molecular weight (DA)
32kD
Immunogen
Synthesized peptide derived from part region of human protein
Specificity
GEM Polyclonal Antibody detects endogenous levels of protein.
Formulation
Liquid in PBS containing 50% glycerol, and 0.02% sodium azide.
Dilution rate
WB 1:500-2000 ELISA 1:5000-20000
Purification process (Immunogen)
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Background
The protein encoded by this gene belongs to the RAD/GEM family of GTP-binding proteins. It is associated with the inner face of the plasma membrane and could play a role as a regulatory protein in receptor-mediated signal transduction. Alternative splicing occurs at this locus and two transcript variants encoding the same protein have been identified. [provided by RefSeq, Jul 2008],
Function
function:Could be a regulatory protein, possibly participating in receptor-mediated signal transduction at the plasma membrane. Has guanine nucleotide-binding activity but undetectable intrinsic GTPase activity.,induction:By mitogens.,PTM:Phosphorylated on tyrosine residues.,similarity:Belongs to the small GTPase superfamily. RGK family.,subunit:Interacts with calmodulin in a Ca(2+)-dependent manner. Binds ROCK1.,tissue specificity:Most abundant in thymus, spleen, kidney, lung, and testis. Less abundant in heart, brain, liver and skeletal muscle.,
Protein name
GTP-binding protein GEM (GTP-binding mitogen-induced T-cell protein) (RAS-like protein KIR)
Human protein sequence Database
P55040
Mouse protein sequence database
P55041
Rat protein sequence database
Cellular localization
Cell membrane; Peripheral membrane protein; Cytoplasmic side.
Tissue expression
Most abundant in thymus, spleen, kidney, lung, and testis. Less abundant in heart, brain, liver and skeletal muscle.
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