Molecular weight (DA)
23kD
Immunogen
Synthesized peptide derived from part region of human protein
Specificity
RIT2 Polyclonal Antibody detects endogenous levels of protein.
Formulation
Liquid in PBS containing 50% glycerol, and 0.02% sodium azide.
Dilution rate
WB 1:500-2000 ELISA 1:5000-20000
Purification process (Immunogen)
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Background
RIN belongs to the RAS (HRAS; MIM 190020) superfamily of small GTPases (Shao et al., 1999 [PubMed 10545207]).[supplied by OMIM, Mar 2008],
Function
function:Binds and exchanges GTP and GDP.,miscellaneous:Shows rapid uncatalyzed guanine nucleotide dissociation rates, which are much faster than those of most Ras subfamily members.,similarity:Belongs to the small GTPase superfamily. Ras family.,subunit:Interacts with MLLT4, the C-terminal domain of RALGDS and RLF, but not with RIN1 and PIK3CA. RLF binds exclusively to the active GTP-bound form (By similarity). Binds calmodulin.,tissue specificity:Neuron-specific.,
Protein name
GTP-binding protein Rit2 (Ras-like protein expressed in neurons) (Ras-like without CAAX protein 2)
Human protein sequence Database
Q99578
Mouse protein sequence database
P70425
Rat protein sequence database
Q5BJQ5
Cellular localization
Nucleus . Cell membrane . Colocalizes with PLXNB3 at the plasma membrane (PubMed:16122393). .
Tissue expression
Neuron-specific.
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