Molecular weight (DA)
42kD
Immunogen
Synthesized peptide derived from human protein . at AA range: 160-240
Specificity
LHX4 Polyclonal Antibody detects endogenous levels of protein.
Formulation
Liquid in PBS containing 50% glycerol, and 0.02% sodium azide.
Dilution rate
WB 1:500-2000 ELISA 1:5000-20000
Purification process (Immunogen)
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Background
This gene encodes a member of a large protein family which contains the LIM domain, a unique cysteine-rich zinc-binding domain. The encoded protein is a transcription factor involved in the control of differentiation and development of the pituitary gland. Mutations in this gene cause combined pituitary hormone deficiency 4. [provided by RefSeq, Dec 2010],
Function
disease:A chromosomal aberration involving LHX4 may be a cause of acute lymphoblastic leukemia. Translocation t(1;14)(q25;q32) with IGHG1.,disease:Defects in LHX4 are the cause of Machinis syndrome [MIM:606606]. It is characterized by short stature, pituitary and cerebellar defects, and small sella turcica.,function:May play a critical role in the development of respiratory control mechanisms and in the normal growth and maturation of the lung.,similarity:Contains 1 homeobox DNA-binding domain.,similarity:Contains 1 LIM zinc-binding domain.,similarity:Contains 2 LIM zinc-binding domains.,
Protein name
LIM/homeobox protein Lhx4 (LIM homeobox protein 4)
Human protein sequence Database
Q969G2
Mouse protein sequence database
P53776
Rat protein sequence database
Cellular localization
Nucleus .
Tissue expression
Muscle,Placenta,
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