Molecular weight (DA)
505kD
Immunogen
Synthesized peptide derived from human protein . at AA range: 200-280
Specificity
LRP1B Polyclonal Antibody detects endogenous levels of protein.
Formulation
Liquid in PBS containing 50% glycerol, and 0.02% sodium azide.
Dilution rate
IHC-p 1:50-300. IF 1:50-200
Purification process (Immunogen)
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Background
This gene encodes a member of the low density lipoprotein (LDL) receptor family. These receptors play a wide variety of roles in normal cell function and development due to their interactions with multiple ligands. Disruption of this gene has been reported in several types of cancer. [provided by RefSeq, Jun 2016],
Function
function:Potential cell surface proteins that bind and internalize ligands in the process of receptor-mediated endocytosis.,miscellaneous:The gene is preferentially inactivated in one histological type of lung cancer (non-small cell lung cancer (NSCLC)). May thus play an important role in tumorigenesis of NSCLCs.,similarity:Belongs to the LDLR family.,similarity:Contains 14 EGF-like domains.,similarity:Contains 32 LDL-receptor class A domains.,similarity:Contains 36 LDL-receptor class B repeats.,subunit:Binds LRPAP1, PLAU, PLAT and SERPINE1; binding is followed by internalization and degradation of the ligands.,tissue specificity:Expressed in thyroid gland and in salivary gland, as well as in adult and fetal brain.,
Protein name
Low-density lipoprotein receptor-related protein 1B (LRP-1B) (Low-density lipoprotein receptor-related protein-deleted in tumor) (LRP-DIT)
Human protein sequence Database
Q9NZR2
Mouse protein sequence database
Q9JI18
Rat protein sequence database
Cellular localization
Membrane ; Single-pass type I membrane protein .
Tissue expression
Expressed in thyroid gland and in salivary gland, as well as in adult and fetal brain.
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