Molecular weight (DA)
209kD
Immunogen
Synthesized peptide derived from human protein . at AA range: 290-370
Specificity
LRP4 Polyclonal Antibody detects endogenous levels of protein.
Formulation
Liquid in PBS containing 50% glycerol, and 0.02% sodium azide.
Dilution rate
WB 1:500-2000 ELISA 1:5000-20000
Purification process (Immunogen)
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Background
This gene encodes a member of the low-density lipoprotein receptor-related protein family. The encoded protein may be a regulator of Wnt signaling. Mutations in this gene are associated with Cenani-Lenz syndrome. [provided by RefSeq, May 2010],
Function
function:Potential cell surface endocytic receptor, which binds and internalizes extracellular ligands for degradation by lysosomes.,similarity:Belongs to the LDLR family.,similarity:Contains 20 LDL-receptor class B repeats.,similarity:Contains 3 EGF-like domains.,similarity:Contains 8 LDL-receptor class A domains.,tissue specificity:Expressed in several regions of the brain.,
Gene Name
LRP4 KIAA0816 LRP10 MEGF7
Protein name
Low-density lipoprotein receptor-related protein 4 (LRP-4) (Multiple epidermal growth factor-like domains 7)
Human protein sequence Database
O75096
Mouse protein sequence database
Q8VI56
Rat protein sequence database
Q9QYP1
Cellular localization
Cell membrane ; Single-pass type I membrane protein .
Tissue expression
Expressed in bone; present in osteoblasts and osteocytes. No expression is observed in osteoclast. Expressed in several regions of the brain.