Molecular weight (DA)
57kD
Immunogen
Synthesized peptide derived from human protein . at AA range: 380-460
Specificity
MARCO Polyclonal Antibody detects endogenous levels of protein.
Formulation
Liquid in PBS containing 50% glycerol, and 0.02% sodium azide.
Dilution rate
WB 1:500-2000 ELISA 1:5000-20000
Purification process (Immunogen)
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Background
The protein encoded by this gene is a member of the class A scavenger receptor family and is part of the innate antimicrobial immune system. The protein may bind both Gram-negative and Gram-positive bacteria via an extracellular, C-terminal, scavenger receptor cysteine-rich (SRCR) domain. In addition to short cytoplasmic and transmembrane domains, there is an extracellular spacer domain and a long, extracellular collagenous domain. The protein may form a trimeric molecule by the association of the collagenous domains of three identical polypeptide chains. [provided by RefSeq, Jul 2008],
Function
function:Binds Gram-positive and Gram-negative bacteria.,similarity:Contains 1 collagen-like domain.,similarity:Contains 1 SRCR domain.,
Protein name
Macrophage receptor MARCO (Macrophage receptor with collagenous structure) (Scavenger receptor class A member 2)
Human protein sequence Database
Q9UEW3
Mouse protein sequence database
Q60754
Rat protein sequence database
Cellular localization
Cell membrane ; Single-pass type II membrane protein .
Tissue expression
Expressed in alveolar macrophages (at protein level). Detected in macrophages from various tissues including thymus, kidney, Kupffer cells of liver, and spleen (PubMed:9468508).
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