Molecular weight (DA)
92kD
Immunogen
Synthesized peptide derived from human protein . at AA range: 80-160
Specificity
CDHR5 Polyclonal Antibody detects endogenous levels of protein.
Formulation
Liquid in PBS containing 50% glycerol, and 0.02% sodium azide.
Dilution rate
WB 1:500-2000; IF/ICC 1:100-500;ELISA 1:5000-20000
Purification process (Immunogen)
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Background
cadherin related family member 5(CDHR5) Homo sapiens This gene is a novel mucin-like gene that is a member of the cadherin superfamily. While encoding nonpolymorphic tandem repeats rich in proline, serine and threonine similar to mucin proteins, the gene also contains sequence encoding calcium-binding motifs found in all cadherins. The role of the hybrid extracellular region and the specific function of this protein have not yet been determined. Alternatively spliced transcript variants encoding different isoforms have been described. [provided by RefSeq, Jan 2010],
Function
function:Acts as a calcium-dependent cell adhesion protein.,PTM:N- and O-glycosylated.,similarity:Contains 4 cadherin domains.,tissue specificity:Highest expression in kidney, liver, colon and small intestine. In kidney, expressed apically along brush border of proximal convoluted tubule but not in cortical collecting ducts. Isoform 1 is expressed primarily in adult small intestine and colon. Isoform 2 is highly expressed in fetal liver.,
Gene Name
CDHR5 MUCDHL MUPCDH UNQ2781/PRO7168
Protein name
Cadherin-related family member 5 (Mu-protocadherin) (Mucin and cadherin-like protein)
Human protein sequence Database
Q9HBB8
Mouse protein sequence database
Q8VHF2
Rat protein sequence database
Q9JIK1
Cellular localization
Apical cell membrane ; Single-pass type I membrane protein . Cell projection, microvillus membrane ; Single-pass type I membrane protein .
Tissue expression
Highest expression in kidney, liver, colon and small intestine. In kidney, expressed apically along brush border of proximal convoluted tubule but not in cortical collecting ducts. Isoform 1 is expressed primarily in adult small intestine and colon. Isoform 2 is highly expressed in fetal liver (PubMed:12167596). Expressed in duodenum with higher expression in enterocytes along the villus axis and lower expression in crypts (at protein level) (PubMed:24725409).
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