Molecular weight (DA)
41kD
Immunogen
Synthesized peptide derived from human protein . at AA range: 40-120
Specificity
MUC7 Polyclonal Antibody detects endogenous levels of protein.
Formulation
Liquid in PBS containing 50% glycerol, and 0.02% sodium azide.
Dilution rate
WB 1:500-2000 ELISA 1:5000-20000
Purification process (Immunogen)
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Background
mucin 7, secreted(MUC7) Homo sapiens This gene encodes a small salivary mucin, which is thought to play a role in facilitating the clearance of bacteria in the oral cavity and to aid in mastication, speech, and swallowing. The central domain of this glycoprotein contains tandem repeats, each composed of 23 amino acids. This antimicrobial protein has antibacterial and antifungal activity. The most common allele contains 6 repeats, and some alleles may be associated with susceptibility to asthma. Alternatively spliced transcript variants with different 5' UTR, but encoding the same protein, have been found for this gene. [provided by RefSeq, Oct 2014],
Function
disease:MUC7 alleles are associated with susceptibility to asthma [MIM:600807]. The MUC7*5 allele is rarer in the atopic asthmatics than in the atopic non-asthmatics. Comparison of all atopic individuals with all nonatopic shows no difference, while comparison of all asthmatic individuals with all non-asthmatic shows that the asthmatic group has reduced MUC7*5 frequency. The significantly lower frequency of the MUC7*5 allele in individuals with atopic asthma was explained by the possible association between alleles and different interactions with bacteria, since the glycosylated domain is thought to be responsible, at least in part, for the bacterial binding that allows bacteria to be cleared from the epithelial surfaces.,function:May function in a protective capacity by promoting the clearance of bacteria in the oral cavity and aiding in mastication, speech, and swallowing. Binds P.aeru
Protein name
Mucin-7 (MUC-7) (Apo-MG2) (Salivary mucin-7)
Fields
>>Salivary secretion
Human protein sequence Database
Q8TAX7
Mouse protein sequence database
Rat protein sequence database
Cellular localization
Secreted .
Tissue expression
Expressed in salivary gland tissues and only in those that contain mucous acinar cells (e.g. sublingual and submandibular glands) and not in salivary glands containing only serous acinar cells (e.g. parotid gland).
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