Molecular weight (DA)
125kD
Immunogen
Synthesized peptide derived from human protein . at AA range: 560-640
Specificity
MYPC2 Polyclonal Antibody detects endogenous levels of protein.
Formulation
Liquid in PBS containing 50% glycerol, and 0.02% sodium azide.
Dilution rate
WB 1:500-2000 ELISA 1:5000-20000
Purification process (Immunogen)
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Background
This gene encodes a member of the myosin-binding protein C family. This family includes the fast-, slow- and cardiac-type isoforms, each of which is a myosin-associated protein found in the cross-bridge-bearing zone (C region) of A bands in striated muscle. The protein encoded by this locus is referred to as the fast-type isoform. Mutations in the related but distinct genes encoding the slow-type and cardiac-type isoforms have been associated with distal arthrogryposis, type 1 and hypertrophic cardiomyopathy, respectively. [provided by RefSeq, Jul 2012],
Function
function:Thick filament-associated protein located in the crossbridge region of vertebrate striated muscle a bands. In vitro it binds MHC, F-actin and native thin filaments, and modifies the activity of actin-activated myosin ATPase. It may modulate muscle contraction or may play a more structural role.,similarity:Belongs to the immunoglobulin superfamily. MyBP family.,similarity:Contains 3 fibronectin type-III domains.,similarity:Contains 7 Ig-like C2-type (immunoglobulin-like) domains.,
Protein name
Myosin-binding protein C, fast-type (Fast MyBP-C) (C-protein, skeletal muscle fast isoform)
Human protein sequence Database
Q14324
Mouse protein sequence database
Q5XKE0
Rat protein sequence database
Cellular localization
cytosol,myosin filament,
Tissue expression
Epithelium,Fetal skeletal muscle,Pooled,
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