Molecular weight (DA)
92kD
Immunogen
Synthesized peptide derived from human protein . at AA range: 10-90
Specificity
ESCO1 Polyclonal Antibody detects endogenous levels of protein.
Formulation
Liquid in PBS containing 50% glycerol, and 0.02% sodium azide.
Dilution rate
WB 1:500-2000 ELISA 1:5000-20000
Purification process (Immunogen)
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Background
establishment of sister chromatid cohesion N-acetyltransferase 1(ESCO1) Homo sapiens ESCO1 belongs to a conserved family of acetyltransferases involved in sister chromatid cohesion (Hou and Zou, 2005 [PubMed 15958495]).[supplied by OMIM, Mar 2008],
Function
caution:It is uncertain whether Met-1 or Met-2 is the initiator.,domain:The N-terminal region seems to be responsible for the association with chromosomes, thus excluding any involvement of the Zn finger in this process.,function:Acetyltransferase required for the establishment of sister chromatid cohesion and couple the processes of cohesion and DNA replication to ensure that only sister chromatids become paired together. In contrast to the structural cohesins, the deposition and establishment factors are required only during S phase.,PTM:Phosphorylated during mitosis. Phosphorylated upon DNA damage, probably by ATM or ATR.,similarity:Belongs to the acetyltransferase family. GCN5 subfamily.,subcellular location:Nuclear at interphase, associated with chromosomes during mitosis.,tissue specificity:Widely expressed. Expressed in heart, brain, liver, placenta, lung, kidney and pancreas. Hig
Gene Name
ESCO1 EFO1 KIAA1911
Protein name
N-acetyltransferase ESCO1 (EC 2.3.1.-) (CTF7 homolog 1) (Establishment factor-like protein 1) (EFO1p) (hEFO1) (Establishment of cohesion 1 homolog 1) (ECO1 homolog 1) (ESO1 homolog 1)
Human protein sequence Database
Q5FWF5
Mouse protein sequence database
Q69Z69
Rat protein sequence database
Cellular localization
Nucleus . Chromosome . Nuclear at interphase, associated with chromosomes during mitosis. .
Tissue expression
Widely expressed. Expressed in heart, brain, liver, placenta, lung, kidney and pancreas. Highly expressed in muscle.
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