Molecular weight (DA)
92kD
Immunogen
Synthesized peptide derived from human protein . at AA range: 130-210
Specificity
UNC5A Polyclonal Antibody detects endogenous levels of protein.
Formulation
Liquid in PBS containing 50% glycerol, and 0.02% sodium azide.
Dilution rate
WB 1:500-2000 ELISA 1:5000-20000
Purification process (Immunogen)
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Background
UNC5A belongs to a family of netrin-1 (MIM 601614) receptors thought to mediate the chemorepulsive effect of netrin-1 on specific axons. For more information on UNC5 proteins, see UNC5C (MIM 603610).[supplied by OMIM, Apr 2004],
Function
domain:The ZU5 domain mediates the interaction with MAGED1, which participates in the induction of apoptosis.,function:Receptor for netrin required for axon guidance. Mediates axon repulsion of neuronal growth cones in the developing nervous system upon ligand binding. Axon repulsion in growth cones may be caused by its association with DCC that may trigger signaling for repulsion. It also acts as a dependence receptor required for apoptosis induction when not associated with netrin ligand.,induction:By p53/TP53.,miscellaneous:Down-regulated in multiple cancers including colorectal, breast, ovary, uterus, stomach, lung, or kidney cancers.,PTM:Phosphorylated on cytoplasmic tyrosine residues. Phosphorylated by PKC in vitro.,PTM:Proteolytically cleaved by caspases during apoptosis. The cleavage does not take place when the receptor is associated with netrin ligand. Its cleavage by caspases
Gene Name
UNC5A KIAA1976 UNC5H1
Protein name
Netrin receptor UNC5A (Protein unc-5 homolog 1) (Protein unc-5 homolog A)
Human protein sequence Database
Q6ZN44
Mouse protein sequence database
Q8K1S4
Rat protein sequence database
O08721
Cellular localization
Cell membrane ; Single-pass type I membrane protein . Membrane raft . Cell projection, neuron projection . The interaction with PRKCABP regulates its surface expression and leads to its removal from the surface of neurons and growth cones. .
Tissue expression
Brain,PCR rescued clones,Pooled,
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