Molecular weight (DA)
103kD
Immunogen
Synthesized peptide derived from human protein . at AA range: 350-430
Specificity
UNC5B Polyclonal Antibody detects endogenous levels of protein.
Formulation
Liquid in PBS containing 50% glycerol, and 0.02% sodium azide.
Dilution rate
WB 1:500-2000 ELISA 1:5000-20000
Purification process (Immunogen)
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Background
This gene encodes a member of the netrin family of receptors. This particular protein mediates the repulsive effect of netrin-1 and is a vascular netrin receptor. This encoded protein is also in a group of proteins called dependence receptors (DpRs) which are involved in pro- and anti-apoptotic processes. Many DpRs are involved in embryogenesis and in cancer progression. Two alternatively spliced transcript variants have been described for this gene. [provided by RefSeq, Oct 2011],
Function
function:Receptor for netrin required for axon guidance. Mediates axon repulsion of neuronal growth cones in the developing nervous system upon ligand binding. Axon repulsion in growth cones may be caused by its association with DCC that may trigger signaling for repulsion. It also acts as a dependence receptor required for apoptosis induction when not associated with netrin ligand.,induction:By p53/TP53.,miscellaneous:Down-regulated in multiple cancers including colorectal, breast, ovary, uterus, stomach, lung, or kidney cancers.,PTM:Phosphorylated on cytoplasmic tyrosine residues.,PTM:Proteolytically cleaved by caspases during apoptosis. The cleavage does not take place when the receptor is associated with netrin ligand. Its cleavage by caspases is required to induce apoptosis.,similarity:Belongs to the unc-5 family.,similarity:Contains 1 death domain.,similarity:Contains 1 Ig-like (im
Gene Name
UNC5B P53RDL1 UNC5H2 UNQ1883/PRO4326
Protein name
Netrin receptor UNC5B (Protein unc-5 homolog 2) (Protein unc-5 homolog B) (p53-regulated receptor for death and life protein 1)
Human protein sequence Database
Q8IZJ1
Mouse protein sequence database
Q8K1S3
Rat protein sequence database
O08722
Cellular localization
Cell membrane ; Single-pass type I membrane protein . Membrane raft . Associated with lipid rafts. .
Tissue expression
Highly expressed in brain. Also expressed at lower level in developing lung, cartilage, kidney and hematopoietic and immune tissues.
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