Molecular weight (DA)
15kD
Immunogen
Synthesized peptide derived from human protein . at AA range: 40-120
Specificity
NRN1 Polyclonal Antibody detects endogenous levels of protein.
Formulation
Liquid in PBS containing 50% glycerol, and 0.02% sodium azide.
Dilution rate
WB 1:500-2000 ELISA 1:5000-20000
Purification process (Immunogen)
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Background
This gene encodes a member of the neuritin family, and is expressed in postmitotic-differentiating neurons of the developmental nervous system and neuronal structures associated with plasticity in the adult. The expression of this gene can be induced by neural activity and neurotrophins. The encoded protein contains a consensus cleavage signal found in glycosylphoshatidylinositol (GPI)-anchored proteins. The encoded protein promotes neurite outgrowth and arborization, suggesting its role in promoting neuritogenesis. Overexpression of the encoded protein may be associated with astrocytoma progression. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2013],
Function
function:Promotes neurite outgrowth and especially branching of neuritic processes in primary hippocampal and cortical cells.,similarity:Belongs to the neuritin family.,
Human protein sequence Database
Q9NPD7
Mouse protein sequence database
Q8CFV4
Rat protein sequence database
O08957
Cellular localization
Cell membrane ; Lipid-anchor, GPI-anchor . Cell junction, synapse .
Tissue expression
Adrenal cortex,Brain,Uterus,